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. 2018 Sep 5;9:1230. doi: 10.3389/fphys.2018.01230

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Copyright © 2018 Chen, Zhu, Zhou, Zhang, Cai, Wu, Ren, Gao, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of amitriptyline on Nav1.5 currents. (A) Protocols for I_Na eliciting. (B) Representative I_Na in control cells and in cells with acute treatments of amitriptyline. (C) I-V curves for control cells and cells with acute treatments of amitriptyline. (D) Analysis of peak I_Na densities for the acute effect of amitriptyline. (E) Representative I_Na in control cells and cells with long-term treatments of amitriptyline. (F) I-V curves for control cells and cells with long-term treatments of amitriptyline. (G) Analysis of peak I_Na densities for the long-term effect of amitriptyline. ^∗∗∗P < 0.001.