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. 2018 Sep 5;9:1230. doi: 10.3389/fphys.2018.01230

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Copyright © 2018 Chen, Zhu, Zhou, Zhang, Cai, Wu, Ren, Gao, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of amitriptyline on the gating properties of Nav1.5 currents. (A) Protocols for steady-state activation (SSA) recording. (B) SSA curves for the acute effect of amitriptyline. (C) SSA cures for the long-term effect of amitriptyline. (D) Protocols for steady-state inactivation (SSI) recording. (E) SSI curves for the acute effect of amitriptyline. (F) SSI curves for the long-term effect of amitriptyline. (G) Protocols for recovery from inactivation (RFI) recording. (H) RFI curves for the acute effect of amitriptyline. (I) RFI curves for the long-term effect of amitriptyline.