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. 2018 Nov 14;3:27. Originally published 2018 Mar 12. [Version 3] doi: 10.12688/wellcomeopenres.14073.3

Figure 7. Relationships between WGCNA and Chaussabel modules.

Figure 7.

( A) Bipartite graph of the two module types based on the hypergeometric association index in the HIVsetA dataset (acute HIV, N = 28 vs healthy controls, N = 23). Strikingly, Chaussabel modules tend to have the same direction of differential expression (indicated by the rim colour of the Chaussabel modules, red indicating up-regulation in acute HIV, and blue indicating downregulation) as WGCNA modules they map to, indicated by the label colour of the module. ( B) Projection 1 of ( A), showing relationships between Chaussabel modules based on shared WGCNA modules; dense cliques of modules are observed. ( C) Projection 2 of ( A), showing relationships between WGCNA modules based on shared Chaussabel modules. All associations (hypergeometric test) shown are corrected for multiple testing, BH-corrected P-value < 0.05. All outputs were generated using the igraph_plotter function, exporting vertex and edge tables of the bipartite graph and the two projections and importing these into Cytoscape.