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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Expert Opin Drug Discov. 2017 Sep 11;12(12):1181–1185. doi: 10.1080/17460441.2017.1378179

Figure 2.

Figure 2.

Four key areas of interests in drug discovery for chronomedicine. Please see text for details. PPI: protein-protein interaction. PK: pharmacokinetics. Human trials are of critical urgency and importance to validate clock-targeting therapeutics. Established drugs or natural products with known PK and safety profiles are ideally positioned to advance to trials.