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. Author manuscript; available in PMC: 2019 Sep 11.
Published in final edited form as: Org Biomol Chem. 2018 Sep 11;16(35):6450–6459. doi: 10.1039/c8ob01565a

Fig. 3. OxaC and OxaG enzymatic activity.

Fig. 3.

HPLC traces of authentic standards of glandicoline B (1) and meleagrin (2) incubated with OxaC or OxaG and SAM. The traces indicate that OxaG catalyzes methylation of 1 to generate 2, while OxaC catalyzes methylation of both 1 and 2 forming a new metabolite glandicoline C (4) and 3, respectively. The singly methylated product 4 is not a substrate for OxaG.