3.
与HER或VEFR通路相互作用的指定的分子靶向药物
Selected molecular targeted agents interacting with the her or vegf pathways
| 靶向药物 | VEGF-A配基 | VEGFR | EGFR | 其它靶标 |
|
Abbreviations: EGFR=epidermal growth factor receptor; PDGFR=platelet-derived growth factor receptor; VEGF=vascular endothelial growth factor; VEGFR=vascular endothelialb growth factor receptor. Note: Reprinted with permission from the copyright holder ©CIG Media Group, LP 缩写：EGFR：表皮生长因子受体；PDGFR：血小板源性生长因子受体；VEGF：血管内皮生长因子；VEGFR：血管内皮生长因子受体。 注：本图得到版权所有者©CIG Media Group, LP复制许可 | ||||
| 贝伐珠单抗[1] | √ | |||
| 厄洛替尼[2] | √ | |||
| 吉非替尼[52] | √ | |||
| 索拉非尼[58] | √ | PDGFR-β, FLT-3, c-Kit, Raf kinase | ||
| 舒尼替尼[36, 37] | √ | PDGFR-β, FLT-3, c-Kit | ||
| 西地尼布/AZD2171[36, 37] | √ | PDGFR-β, c-Kit | ||
| 凡德他尼[36, 37] | √ | √ | RET | |
| BMS-690514[59] | √ | √ | Pan-HER | |
| PF-00299804[61] | √ | Pan-HER | ||
| 来那替尼/HKI-272[61] | √ | HER2 | ||
| XL647[61] | √ | √ | HER2, EphB4 | |