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. 2018 Sep 11;17:215. doi: 10.1186/s12944-018-0864-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effects of PGE2 on CGRP expression in cultured synovial cells, adipocytes, and the stromal vascular fraction. Synovial cells (SYC), adipocytes (Ad) and the stromal vascular fraction (SVF) were stimulated in vitro with PGE2 (10 μM) or serum-free medium without PGE2 (control, con) for 8 h. CGRP mRNA expression levels were evaluated by RT-PCR. All data are presented as the mean ± standard error (n = 8). *p < 0.05. ^a indicates a statistical difference between PGE2-stimulated and non-stimulated cells in each fraction. ^b indicates a statistical difference when compared to SYC under the same conditions