Table 1.
Summary of NSP gene features
| NSP1 | NSP2 | NSP3 | NSP4 | NSP5 | NSP6 | NSP7 | |
|---|---|---|---|---|---|---|---|
| Orphan genea | X | X | X | X | X | – | – |
| Conserved domains | TSP1, LamG3 | LamG3 | Galectin | CRD | MANEC | Peptidase S8 | γ glutamyl transpeptidase |
| Single copy | – | X | X | – | X | – | – |
| Previously reported | – | X (nb012) | – | – | – | X | X |
| Signal peptide in NSP | X | X | X | X | – | X | – |
| Transmembrane domain | – | – | – | – | X | – | X |
| Protein categoryb | Structural | Structural | Structural | Novel | Novel | Serine peptidase | Metabolic enzyme glutamate |
| Shell Proteinb | X | X | – | X | – | – | X |
| Higher copy number in Hydrozoa compared to anthozoans | – | – | X | – | – | X | – |
| Present in C. shasta polar capsule proteome | X | X | X | – | – | X | X |
| Cnidarian clades found to possess the gene | Anthozoa Medusozoa Myxozoa |
Anthozoa Medusozoa Myxozoa Polypodium |
Medusozoa Myxozoa Polypodium |
Anthozoa Medusozoa Myxozoa Polypodium |
Anthozoa Medusozoa Myxozoa Polypodium |
Anthozoa Medusozoa Myxozoa Polypodium |
Anthozoa Medusozoa Myxozoa Polypodium |
a no known homolog outside of Cnidaria
b as annotated by Balasubramanian et al. [14]