Table 3.
Adverse pregnancy outcomes according to maternal TSH concentration in the first trimester
| Pregnancy outcomes | Normal (n = 1532), n (%) |
eTSH (2.5–4 mIU/L) (n = 142), n (%) | χ2 | P |
|---|---|---|---|---|
| Mother | ||||
| IUGR | 12 (0.8) | 1 (0.7) | 0.00 | 1.00 |
| GDM | 163 (10.6) | 12 (8.5) | 0.67 | 0.42 |
| Gestational hypertension/preeclampsia | 25 (1.6) | 1 (0.7) | 0.25 | 0.62 |
| PROM | 394 (25.7) | 30 (21.1) | 1.45 | 0.23 |
| Placental abruption | 14 (0.9) | 1 (0.7) | 0.00 | 1.00 |
| Placenta previa | 15 (1.0) | 0 (0.0) | 0.52 | 0.47 |
| Premature delivery (< 37 weeks) | 60 (3.9) | 3 (2.1) | 0.72 | 0.40 |
| PPH | 50 (3.3) | 5 (3.5) | 0.03 | 0.87 |
| Delivery method (assisted vaginal delivery or cesarean section) | 95 (25.9) | 7 (23.3) | 0.10 | 0.76 |
| Newborn | ||||
| LBW | 38 (2.5) | 4 (2.8) | 0.00 | 1.00 |
| SGA | 36 (2.3) | 3 (2.1) | 0.00 | 1.00 |
| LGA | 236 (15.4) | 21 (14.8) | 0.04 | 0.84 |
| Apgar score ≤ 7 at 1 or 5 min | 27 (1.8) | 0 (0.0) | 1.55 | 0.21 |
TSH thyroid-stimulating hormone, eTSH elevated thyroid-stimulating hormone, IUGR intrauterine growth restriction, GDM gestational diabetes mellitus, PROM premature rupture of membranes, PPH postpartum hemorrhage, LBW low birth weight, SGA small for gestational age, LGA large for gestational age