Table 1.
Baseline characteristics of 975 chronic kidney disease patients
| Characteristic | TSAT (%) | Ferritin (μg/L) | ||||||
|---|---|---|---|---|---|---|---|---|
| < 10 [n = 41] |
10- < 20 [n = 278] |
20- < 30 [n = 414] |
≥30 [n = 242] |
< 50 [n = 169] |
50- < 100 [n = 219] |
100- < 300 [n = 453] |
≥300 [n = 134] |
|
| Demographics | ||||||||
| Age, yr | 60 ± 12 | 63 ± 12 | 62 ± 11 | 63 ± 11 | 59 ± 13 | 63 ± 11 | 63 ± 11 | 64 ± 11 |
| Male sex – no. (%) | 17 (42) | 151 (54) | 277 (67) | 180 (74) | 59 (35) | 136 (62) | 317 (70) | 113 (84) |
| Race (n, %) | 37 (90) | 263 (95) | 397 (96) | 235 (97) | 159 (94) | 213 (97) | 437 (97) | 123 (92) |
| BMI, kg/m2 | 27.6 ± 4.8 | 29.4 ± 5.7 | 28.3 ± 4.3 | 27.4 ± 4.1 | 26.9 ± 5.6 | 27.9 ± 4.7 | 28.7 ± 4.6 | 29.5 ± 4.0 |
| Systolic blood pressure, mmHg | 135 ± 24 | 140 ± 22 | 139 ± 22 | 139 ± 22 | 133 ± 21 | 138 ± 21 | 140 ± 22 | 145 ± 21 |
| Diabetes Mellitus, n (%) | 6 (15) | 67 (24) | 69 (17) | 36 (15) | 23 (14) | 27 (12) | 99 (22) | 29 (22) |
| Current smoking, n (%) | 6 (15) | 76 (28) | 121 (29) | 72 (30) | 45 (27) | 69 (32) | 127 (28) | 34 (25) |
| Alcohol use, n(%) | 22 (54) | 176 (63) | 298 (72) | 181 (75) | 99 (59) | 147 (67) | 329 (73) | 102 (76) |
| Baseline renal function | ||||||||
| Creatinine (μmol/L) | 85 (73–113) | 90 (79–104) | 92 (81–107) | 95 (80–106) | 85 (74–99) | 92 (79–107) | 93 (83–108) | 93 (84–109) |
| eGFR (ml/min/1.73m2) | 78 ± 26 | 76 ± 23 | 78 ± 22 | 78 ± 22 | 81 ± 26 | 76 ± 23 | 76 ± 22 | 77 ± 23 |
| CKD stage | ||||||||
| Stage I (n, %) | 12 (29) | 84 (30) | 136 (33) | 71 (29) | 56 (33) | 70 (32) | 130 (29) | 47 (35) |
| Stage II (n, %) | 13 (32) | 97 (35) | 140 (34) | 99 (41) | 59 (35) | 72 (33) | 174 (38) | 44 (33) |
| Stage III (n, %) | 10 (24) | 76 (27) | 114 (28) | 60 (25) | 37 (22) | 62 (28) | 126 (28) | 35 (26) |
| Stage IV/V (n, %) | 1 (2) | 7 (3) | 3 (1) | 3 (1) | 2 (1) | 2 (1) | 7 (2) | 3 (2) |
| Urinary albumin excretion (mg/24 h) | 51 (36–139) | 53 (33–140) | 54 (34–111) | 56 (36–112) | 48 (33–104) | 54 (33–107) | 57 (34–128) | 63 (38–121) |
| Laboratory parameters | ||||||||
| Hemoglobin (g/dL) | 12.0 ± 2.1 | 13.6 ± 1.3 | 14.2 ± 1.2 | 14.4 ± 1.0 | 13.0 ± 0.6 | 13.9 ± 1.1 | 14.2 ± 1.2 | 14.5 ± 1.4 |
| MCV (fL) | 82 ± 8 | 89 ± 5 | 91 ± 4 | 92 ± 4 | 88 ± 7 | 91 ± 4 | 91 ± 4 | 92 ± 6 |
| Ferritin (μg/L) | 16 (8–28) | 102 (56–175) | 132 (72–235) | 168 (101–276) | 29 (17–40) | 74 (62–87) | 167 (130–214) | 417 (343–553) |
| TSAT (%) | 7 ± 2 | 16 ± 2 | 24 ± 3 | 37 ± 7 | 18 ± 2 | 24 ± 2 | 26 ± 9 | 29 ± 11 |
| Serum iron (μmol/L) | 6 ± 2 | 11 ± 2 | 16 ± 3 | 22 ± 4 | 13 ± 5 | 15 ± 5 | 16 ± 5 | 17 ± 6 |
| hs-CRP (mg/dL)a | 2.7 (1.1–7.9) | 4.1 (1.7–7.0) | 2.1 (1.1–4.1) | 2.0 (1.1–3.9) | 2.0 (0.9–5.1) | 2.2 (1.2–5.1) | 2.6 (1.3–4.7) | 2.4 (1.5–4.9) |
| Albumin (g/L)a | 42 ± 2 | 43 ± 3 | 43 ± 3 | 44 ± 3 | 43 ± 3 | 43 ± 3 | 44 ± 3 | 44 ± 3 |
| Total cholesterol (mmol/L) | 5.1 ± 1.2 | 5.5 ± 1.2 | 5.5 ± 1.0 | 5.5 ± 1.0 | 5.2 ± 1.2 | 5.5 ± 1.1 | 5.5 ± 1.1 | 5.7 ± 1.2 |
| Glucose (mmol/L) | 5.8 ± 2.1 | 5.9 ± 1.9 | 5.5 ± 1.5 | 5.5 ± 1.6 | 5.4 ± 1.8 | 5.3 ± 1.3 | 5.8 ± 1.7 | 5.9 ± 1.8 |
Normally distributed variables are shown as mean with standard deviation, whereas skewed variables are shown as medians with interquartile range. aAlbumin and hs-CRP data were available in 717 patients