Table 2.

Model Parameters With Population Values for ICING Model.

Symbol	Meaning	Value	Range	Units
$P_G$	Patient endogenous glucose removal	0.006	$\left[0,1\right]$	1/min
$S_I$	Insulin sensitivity	0.002	$[0.5\times {10}^{-4},12\times {10}^{-4}]$	l/mU/min
${\mathrm{\alpha }}_G$	Saturation of insulin-stimulated glucose	0.0154	Fixed	l/mU
$EG{P}_b$	Basal endogenous glucose production	1.16	$\left[0,5\right]$	mmol/l
$CNS$	Insulin independent central nervous system glucose uptake	0.3	Fixed	mmol/min
$V_G$	Glucose distribution volume	13.3	$\left[0,50\right]$	l
$V_I$	Insulin distribution volume	3.15	Fixed	l
${\alpha }_I$	Saturation of plasma insulin disappearance	0.0017	Fixed	l/mU
$n_C$	Rate parameter	0.003	Fixed	1/min
$n_I$	Transcapillary diffusion rate	0.003	Fixed	l/min
$n_K$	kidney clearance rate of insulin from plasma	0.0542	Fixed	1/min
$n_L$	Patient specific liver clearance	0.1578	Fixed	l/mU
$d_1$	Transport rate	0.0347	Fixed	1/min
$d_2$	Transport rate	0.0069	Fixed	1/min
$P_{max}$	Saturation value of $x_5$	6.11	Fixed	1/min