Table 2.
miRNAs that regulate ESR1/ERα
| miRNA | Effects on ESR1/ERα and known mechanisms of ER regulation | References |
|---|---|---|
| miR-1 | Suppresses ESR1 expression | [7] |
| miR-9 | Suppresses ESR1 expression ➢ Directly targets ESR1 |
[7, 11, 125] |
| miR-18a/b | Suppresses ESR1 expression ➢ Directly targets ESR1 Inhibits ERα transcriptional activity |
[7, 11, 57, 82] |
| miR-19a/b | Suppresses ESR1 expression ➢ Directly targets ESR1 Inhibits ERα transcriptional activity |
[57] |
| miR-20a/b | Suppresses ESR1 expression ➢ Directly targets ESR1 ➢ Directly targets NCOA3 Inhibits ERα transcriptional activity |
[57] |
| miR-22 | Suppresses ESR1 expression ➢ Directly targets ESR1 ➢ Directly targets SP1 |
[7–9, 11] |
| miR-26a/b | Suppresses ESR1 expression ➢ Directly targets ESR1 |
[126, 127] |
| miR-93 | Suppresses ESR1 expression | [11] |
| miR-103 | Suppresses ESR1 expression | [7] |
| miR-107 | Suppresses ESR1 expression | [7] |
| miR-122 | Suppresses ESR1 expression | [7] |
| miR-129 | Suppresses ESR1 expression | [7] |
| miR-130a/b | Suppresses ESR1 expression | [7, 11] |
| miR-145 | Suppresses ESR1 expression, but does not affect ESR1 or ERα stability ➢ Directly targets ESR1 |
[128] |
| miR-146b | Suppresses ESR1 expression | [7] |
| miR-181a-d | Suppresses ESR1 expression | [11] |
| miR-192 | Suppresses ESR1 expression ➢ Directly targets ESR1 |
[129] |
| miR-193b | Suppresses ESR1 expression ➢ Directly targets NCOA3 |
[11, 125] |
| miR-206 | Suppresses ESR1 expression and ER target genes ➢ Directly targets ESR1 ➢ Directly targets NCOA1 and NCOA3 ➢ Directly targets GATA3 ➢ Directly targets MET |
[1, 7, 11–14] |
| miR-219 | Suppresses ESR1 expression | [11] |
| miR-221 | Suppresses ESR1 expression ➢ Directly targets ESR1 |
[8, 11] |
| miR-222 | Suppresses ESR1 expression ➢ Directly targets ESR1 |
[7, 8, 11] |
| miR-301a/b | Suppresses ESR1 expression | [11] |
| miR-302a-e | Suppresses ESR1 expression | [11] |
| miR-335 | Suppresses ESR1 expression ➢ Directly targets ESR1 |
[130] |
| miR-372 | Suppresses ESR1 expression | [11] |
| miR-373 | Suppresses ESR1 expression | [11] |
| miR-517a/c | Suppresses ESR1 expression | [11] |
| miR-520a-e | Suppresses ESR1 expression | [11] |
| miR-548p | Suppresses ESR1 expression | [7] |
| miR-583 | Suppresses ESR1 expression | [7] |
| miR-590 | Suppresses ESR1 expression | [7] |
| miR-643 | Suppresses ESR1 expression | [7] |
| miR-874 | Suppresses ESR1 expression | [7] |
| miR-885 | Suppresses ESR1 expression | [7] |
| miR-934 | Suppresses ESR1 expression | [7] |
| miR-1231 | Suppresses ESR1 expression | [7] |