Table 3.
miRNAs regulated by estrogen/ERα activation
| miRNA | Known mechanisms of regulation by estrogen/ERα | References |
|---|---|---|
| miRNAs upregulated by estrogen/ERα | ||
| let-7a-g/i | Located in the intragenic region of an estradiol-regulated gene | [32, 57] |
| miR-7 | [8, 39] | |
| miR-9 | [131] | |
| miR-17 | ERα-induced MYC/c-MYC upregulation; c-MYC interaction with the miR-17-92 promoter | [32, 39, 57, 59] |
| miR-18a | [57] | |
| miR-19a/b | [8, 57] | |
| miR-20a | ERα-induced MYC/c-MYC upregulation; c-MYC interaction with the miR-17-92 promoter | [8, 39, 57, 59] |
| miR-21 | Contains ERα binding sites in regulatory region | [32, 39, 44, 57, 59] |
| miR-23a | Contains ERα binding sites in regulatory region | [32] |
| miR-24 | [132] | |
| miR-25 | [39, 57] | |
| miR-27b | [39, 67] | |
| miR-29a | [39] | |
| miR-30b/c | Located in the intragenic region of an estradiol-regulated gene | [32] |
| miR-32 | [57] | |
| miR-34c | [39] | |
| miR-92a/b | [57, 59, 132] | |
| miR-93 | Requires estrogen metabolism-mediated oxidative stress | [57, 132, 133] |
| miR-98 | [32, 57] | |
| miR-99b | [132] | |
| miR-101 | [57] | |
| miR-103 | [32, 132] | |
| miR-106a/b | [8, 57, 59] | |
| miR-107 | [32] | |
| miR-124 | [39] | |
| miR-127 | [39] | |
| miR-129 | [59] | |
| miR-148a | [39] | |
| miR-149 | [39] | |
| miR-181d | [39] | |
| miR-191 | [39, 132] | |
| miR-196a | Contains ERα binding site in promoter region | [134] |
| miR-200a-c | [32, 132] | |
| miR-203 | [32] | |
| miR-206 | [39] | |
| miR-210 | [39] | |
| miR-301a | [39] | |
| miR-320a/c | [132] | |
| miR-424 | [32, 57] | |
| miR-450 | [57] | |
| miR-489 | [57] | |
| miR-503 | [135] | |
| miR-542 | [57] | |
| miR-638 | [132] | |
| miR-1275 | [132] | |
| miR-1915 | [132] | |
| miRNAs downregulated by estrogen/ERα | ||
| let-7a/c/f/g | Transcriptionally repressed by estradiol-induced ER | [40, 132] |
| miR-9 | Located in the intragenic region of an estradiol-regulated gene | [32] |
| miR-15b | [132] | |
| miR-21 | Mediated by AF-1; Transcriptionally repressed by estradiol-induced ER; Contains ERα binding sites in promoter/regulatory region; Mediated by unliganded ERα | [40–44, 132] |
| miR-22 | [57, 59] | |
| miR-23b | Transcriptionally repressed by estradiol-induced ER | [40] |
| miR-26a/b | [40, 132] | |
| miR-27a/b | Contains ERα binding sites in regulatory region; Transcriptionally repressed by estradiol-induced ER | [32, 40, 57] |
| miR-127 | [59] | |
| miR-143 | [32] | |
| miR-148a | [136] | |
| miR-181a/b/d | Contains ERα binding sites in regulatory region; Transcriptionally repressed by estradiol-induced ER; Mediated by unliganded ERα | [40, 57, 137] |
| miR-198 | [57] | |
| miR-200c | [40] | |
| miR-206 | [13] | |
| miR-221/222 | Contains ERα binding sites in promoter region | [12] |
| miR-302b | [32] | |
| miR-487b | [57] | |
| miR-494 | [57] | |
| miR-500 | [57] | |
| miR-506 | [32] | |
| miR-519e | [8] | |
| miR-524 | [32] | |
| miR-584 | [57] | |
| miR-663 | [57] | |
| miR-671 | [57] | |
| miR-1228 | [8] | |
| miR-1826 | [132] | |