. 2018 Sep 12;16:57. doi: 10.1186/s12964-018-0266-6

Table 3.

Post-translational modifications of FOXM1

PTM	Enzyme	Effect	Cell cycle	FOXM1 isoform
Phosphorylation
T620,T627,S672	Cyclin D-CDK4/6[6]	Transcriptional activity^a stabilization^a	G1 → S	FOXM1c
S331	Raf/MEK/MAPK [60]	Nuclear translocation^a	Late S	FOXM1c
S704	Raf/MEK/MAPK [60]	Transcriptional activity^a	Late S	FOXM1c
T600,T611,S638	Cyclin A/E-Cdk2 [62, 63]	Transcriptional activity^a	G2/M	FOXM1c
T596	Cyclin B1-Cdk1 [64]	Transcriptional activity^a	G2/M	FOXM1b
S678	Cyclin B1-Cdk1 [65]	Transcriptional activity^a	Late G2	FOXM1b
S507,S657, T585	Cyclin B1-Cdk1 [131]	Transcriptional activity^a	G2/M	FOXM1b
S715,S724	Plk1 [64]	Transcriptional activity^a	G2 → M/M	FOXM1b
S361	Chk2 [66]	stabilization^a	DDR	FOXM1b
S251	^c [59]	CDK1-dependent phosphorylation^a	G2/M	FOXM1b
S474	GSK3 [67]	degradation^a		FOXM1b
Ubiquitination
-	APC/C-Cdh1 [71, 72]	degradation^a	Late M/Early G1	FOXM1
-	CRL4-VprBP [73]	degradation^a	G1/S	FOXM1
-	SCF/FBXO31 [74]	degradation^a	G2 → M	FOXM1
-	SCF/FBXL2 [132]	degradation^a		FOXM1
-(K48)	FBXW7 [67]	degradation^a		FOXM1
-(K48)	RNF8,RNF168 [75]	degradation^a	(DDR)	FOXM1
De-ubiquitination
-	USP5 [67]	Nuclear translocation^a		FOXM1
(K48)	OTUB1 [76, 77]	degradation^b		FOXM1
SUMOylation
Lys132,144,201,218,356,368,415,440,443,460,478,495(SUMO2)	^c [78]	Transcriptional activity^a Nuclear translocation^a	G2/M	FOXM1c
Lys463(SUMO1)	PIASy [79]	Transcriptional activity^a		FOXM1b
Lys201,218,460,478,495(SUMO1)	Ubc9 [80]	Cytoplasmic translocation^a Cdh1-mediated degradation^a	(CDR)	FOXM1c
-(SUMO1,2,3)	Ubc9,PIAS1 [81]	Cytoplasmic translocation^a stabilization^b		FOXM1b
Lys201,218,341,445,462,480(SUMO1)	^c [68]	Cytoplasmic translocation^a stabilization^b	Late M	FOXM1b
Acetylation
Lys63,422,440,603,614	CBP/p300 [82]	stabilization^a DNA-binding ability^aTranscriptional activity^a	G2/M	FOXM1c
Methylation
-	SETD3 [83]	Transcriptional activity^b		FOXM1

K48 Lys48-linked poly-ubiquitin chains, DDR DNA-damage response, CDR cytotoxic drug response

^a: Promoting

^b: Inhibition

^c: not clear

→ Transition