Table 3.
PTM | Enzyme | Effect | Cell cycle | FOXM1 isoform |
---|---|---|---|---|
Phosphorylation | ||||
T620,T627,S672 | Cyclin D-CDK4/6[6] | Transcriptional activitya stabilizationa |
G1 → S | FOXM1c |
S331 | Raf/MEK/MAPK [60] | Nuclear translocationa | Late S | FOXM1c |
S704 | Raf/MEK/MAPK [60] | Transcriptional activitya | Late S | FOXM1c |
T600,T611,S638 | Cyclin A/E-Cdk2 [62, 63] | Transcriptional activitya | G2/M | FOXM1c |
T596 | Cyclin B1-Cdk1 [64] | Transcriptional activitya | G2/M | FOXM1b |
S678 | Cyclin B1-Cdk1 [65] | Transcriptional activitya | Late G2 | FOXM1b |
S507,S657, T585 | Cyclin B1-Cdk1 [131] | Transcriptional activitya | G2/M | FOXM1b |
S715,S724 | Plk1 [64] | Transcriptional activitya | G2 → M/M | FOXM1b |
S361 | Chk2 [66] | stabilizationa | DDR | FOXM1b |
S251 | c [59] | CDK1-dependent phosphorylationa | G2/M | FOXM1b |
S474 | GSK3 [67] | degradationa | FOXM1b | |
Ubiquitination | ||||
- | APC/C-Cdh1 [71, 72] | degradationa | Late M/Early G1 | FOXM1 |
- | CRL4-VprBP [73] | degradationa | G1/S | FOXM1 |
- | SCF/FBXO31 [74] | degradationa | G2 → M | FOXM1 |
- | SCF/FBXL2 [132] | degradationa | FOXM1 | |
-(K48) | FBXW7 [67] | degradationa | FOXM1 | |
-(K48) | RNF8,RNF168 [75] | degradationa | (DDR) | FOXM1 |
De-ubiquitination | ||||
- | USP5 [67] | Nuclear translocationa | FOXM1 | |
(K48) | OTUB1 [76, 77] | degradationb | FOXM1 | |
SUMOylation | ||||
Lys132,144,201,218,356,368,415,440,443,460,478,495(SUMO2) | c [78] | Transcriptional activitya Nuclear translocationa |
G2/M | FOXM1c |
Lys463(SUMO1) | PIASy [79] | Transcriptional activitya | FOXM1b | |
Lys201,218,460,478,495(SUMO1) | Ubc9 [80] | Cytoplasmic translocationa Cdh1-mediated degradationa |
(CDR) | FOXM1c |
-(SUMO1,2,3) | Ubc9,PIAS1 [81] | Cytoplasmic translocationa stabilizationb |
FOXM1b | |
Lys201,218,341,445,462,480(SUMO1) | c [68] | Cytoplasmic translocationa stabilizationb |
Late M | FOXM1b |
Acetylation | ||||
Lys63,422,440,603,614 | CBP/p300 [82] | stabilizationa DNA-binding abilityaTranscriptional activitya |
G2/M | FOXM1c |
Methylation | ||||
- | SETD3 [83] | Transcriptional activityb | FOXM1 |
K48 Lys48-linked poly-ubiquitin chains, DDR DNA-damage response, CDR cytotoxic drug response
a: Promoting
b: Inhibition
c: not clear
→ Transition