Table 5.

Inhibitors of FOXM1 whose mechanism has been elucidated

Inhibitors	Mechanism	Effect	Cancer cells
Thiazolidinediones	Inhibit Sp1	mRNA exprssionb	hepatoma [95]
Diarylheptanoids	Inhibit Gli1	mRNA and protein exprssionb	pancreatic cancer [96]
RCM-1	increase ubiquitination	protein degradationa	osteosarcoma [99]
Thiostrepton	Interact with FOXM1	binding of FOXM1 to target sitesb	breast cancer [98]
honokiol	Interact with FOXM1	binding of FOXM1 to target sitesb	osteosarcoma [100]
FDI-6	Block FOXM1 DBD	binding of FOXM1 to target sitesb	MCF-7[128]
FOXM1 Apt	target FOXM1 DBD	binding of FOXM1 to target sitesb	HEK 293 T [136]
Peptide 9R-P201	target FOXM1 DBD	FOXM1 and garget gene expressionb	HepG2 [137]

^a: Promoting;

^b: Inhibition