. 2018 Sep 12;16:170. doi: 10.1186/s12916-018-1136-1

Table 4.

Multivariate models showing independent association of sera proteomes and phosphorylated protein in liver associated with advanced liver fibrosis and a higher percentage of collagen

Independent predictors of advanced liver fibrosis
Predictor	Odds ratio	Lower 95% CI	Upper 95% CI
Model with RPMA proteins^a
AST, per 1 U/L	1.037	1.006	1.07*
Tyk2 Y1054/1055, per 1 unit	1.458	1.177	1.807***
ALDH, per 1 unit	0.873	0.783	0.973*
Model with MS proteins
Apolipoprotein C-II precursor, per 1 unit	0.757	0.612	0.936*
Apolipoprotein A-I preproprotein, per 1 unit	1.086	1.036	1.138***
Vitamin K-dependent protein S preproprotein, per 1 unit	1.591	1.221	2.071***
Independent predictors of higher percentage collagen
	Beta		Std. err.
Model with RPMA proteins^a
ASK1 S83, per 1 unit	− 0.654		0.280*
Met Y1234/1235, per 1 unit	0.450		0.167**
p38 MAPK T180/Y182, per 1 unit	0.290		0.072***
IL-10, per 1 unit	1.197		0.255***
LIMK1 T508/LIMK2 T505, per 1 unit	− 0.386		0.130**
Model with MS proteins
Alpha-2-macroglobulin precursor, per 1 unit	0.100		0.026***
Coagulation factor V precursor, per 1 unit	− 0.159		0.062*

^a Liver tissue RPMA proteins were divided by 1000, MS proteins multiplied by 100 for presentation purposes

*p < 0.05, **p < 0.01, ***p < 0.001