Table 1:

List of abbreviations.

Variable	Name
1compartment	One compartment model (O’Flaherty 1981), shown in Figure 1.
3compartment	Three compartment model (Jamei et al. 2009), shown in Figure 1.
3compartmentss	Three compartment steady state model (Wetmore et al. 2012; Wetmore 2015).
BW	Body weight.
Css	Average plasma concentration of a chemical at steady state.
Clint	In vitro intrinsic hepatic clearance.
Clmetabolism	Whole liver hepatic clearance, scaled from Clint.
Clwell–stirred	Hepatic clearance modeled with well-stirred approximation using Clmetabolism.
fub	Fraction unbound, in vitro ratio of unbound to total concentration in plasma.
httk	High-throughput toxicokinetics.
kelim	Elimination rate.
kgutabs	Gut absorption rate, default of 1 h−1.
logP	Logarithm (base 10) of octanol to water partition coefficient.
pbtk	Physiologically based toxicokinetic model, shown in Figure 1.
Qcardiac	Cardiac output, blood flow through the heart and lungs.
Qgfr	Glomerular filtration rate.
Qrest	The difference between Qcardiac and the flow to the liver, kidney, and gut.
Qtissue	Blood flow to a tissue.
QSAR	Quantitative structure-activity relationship.
Rblood2plasma	Ratio of the blood concentration of a chemical to the plasma concentration.
SBML	Systems biology markup language.
SMILES	Simplified molecular-input line-entry system.
Vdist	Volume of distribution, the weighted sum of all partition coefficients.