Table 2:

Model parameter and prediction comparison.

Model	Hepatic clearance	Partition coefficients	Fraction unbound	Hematocrit	Molecular weight	Ratio of blood to plasma	Elimination rate*	Volume of distribution*	Dynamic prediction	Steady state prediction
pbtk	Yes	Yes	Yes	Yes	Yes	Yes	No	No	Yes	Yes
1compartment	No	No	No	No	Yes	No	Yes	Yes	Yes	Yes
3compartment	Yes	Yes	Yes	Yes	Yes	Yes	No	No	Yes	Yes
3compartmentss	Yes	No	Yes	No	Yes	No	No	No	No	Yes

^*Partition coefficients are needed in calculating V_dist. Clearances and f_ub are needed in calculating k_elim.