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. 2018 Aug 7;8(16):4409–4428. doi: 10.7150/thno.26467

Figure 6.

Figure 6

miR-125a-3p mimic inhibits cell migration and proliferation by inhibiting Chi3L1 expression. (A) Trans-well migration assays of A549 and H460 cell lines treated with miR-125a-3p mimic. *, p<0.05. (B) Cell proliferation was measured by MTT assay of A549 and H460 cell treated with miR-125a-3p mimic. *, p<0.05. (C) Expressions of Chi3L1, MMP-9, MMP-13, PCNA, and VEGF with miR-125a-3p treatment were analyzed by Western blotting. (D) Wound healing migration assay of A549 and H460 cells treated with miR-125a-3p mimic. *, p<0.05. (E) Trans-well migration assays of miR-125a-3p mimic-treated A549 cell lines treated with siUSF1. *, p<0.05; #, p<0.05. (F) Trans-well migration assays of miR-125a-3p mimic-treated H460 cell lines treated with siUSF1. *, p<0.05; #, p<0.05. All experiments were repeated three times, and samples in each experiment were prepared in duplicate. Values below the Western blot indicate densitometry analysis using ImageJ software.