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. 2018 Aug 7;8(16):4429–4446. doi: 10.7150/thno.26717

Figure 2.

Figure 2

CAQK-LIPs targeted drug delivery to the injury site and HP hydrogels improved drug retention. (A) Schematic diagram of the specific binding of CAQK peptide-modified liposomes to the injury site. (B) In vivo spectrum imaging system (IVIS) images of the spinal cord injected with indocyanine green (ICG)-labelled peptides at 3 days after spinal cord injury (SCI). (C) Fluorescence spinal cord images of rats injected with 5-carboxyfluorescein (5-FAM)-labelled peptides at 3 days after SCI. Scale bar = 1000 µm. (D) Fluorescence of the active astrocytes after treating with 5-FAM-labelled peptides for 4 h. (E) In vivo spinal cord retention and penetration of the different LIP-ICG complexes measured using IVIS. (F) Quantitative analysis of (E). Scale bar = 50 µm. N= 3, *P < 0.05, **P< 0.01.