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. 2018 Jul 30;8(16):4345–4358. doi: 10.7150/thno.26862

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Alternative splicing (AS) in papillary thyroid carcinoma (PTC). (A) SERPINA1 exhibits differential exon skipping between tissues of thyroid cancer and non-cancerous tissues. (B) Mutually exclusive exon of the FN1 gene is shown with its flanking exons. Histograms represent exon read density and arcs represent splice junctions with the number of reads mapped to the junctions indicated by the thickness of the arc. (C) Binding site analyses of RNA-binding proteins (RBPs) around the 57 skipped exon events reveal enrichment of IGF2BP3.