Table 2.
Plasma NOx levels in SCD sub-phenotypes and comparison group
| SCD category | NOx levels (µMol/L) | SCD category | NOx levels (µMol/L) | P-value |
|---|---|---|---|---|
| Mean ± SD | Mean ± SD | |||
| HbAA Comparison | 59.66±0.75 | HbSS steady state | 46.62±0.06 | 0.02 |
| HbSS steady state | 46.62±0.06 | HbSS VOC | 6.08±0.81 | <0.001 |
| HbSS VOC | 6.08±0.81 | HbSS post VOC | 50.97±1.68 | <0.001 |
| HbSS post VOC | 50.97±1.68 | HbSS steady state | 46.62±0.06 | 0.0216 |
| HbSS VOC | 6.08±0.81 | HbSC VOC | 14.73±1.09 | <0.001 |
| HbSS priapism | 28.97±1.27 | HbSS leg ulcer | 21.70±1.18 | <0.001 |
Notes: P<0.001= highly significant. P<0.05= significant.
Abbreviations: NOx, nitric oxide metabolite; SCD, sickle cell disease; VOC, vaso-occlusive crisis.