Table 2.
Univariable and multivariable Cox regression model analyses of overall survival and disease-specific survival in nomogram cohort
| Variables | Univariable Cox
|
Multivariable Cox
|
||||||
|---|---|---|---|---|---|---|---|---|
| Disease-specific survival
|
Overall survival
|
Disease-specific survival
|
Overall survival
|
|||||
| HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Race | 0.416 | 0.006 | 0.269 | <0.001 | ||||
| Black | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) | ||||
| Others | 1.043 (0.875–1.243) | 0.64 | 0.799 (0.697–0.916) | 0.001 | 0.872 (0.731–1.041) | 0.13 | 0.723 (0.630–0.830) | <0.001 |
| White | 1.085 (0.950–1.240) | 0.229 | 0.895 (0.811–0.987) | 0.027 | 0.955 (0.834–1.092) | 0.499 | 0.839 (0.759–0.926) | 0.001 |
| Sex | <0.001 | <0.001 | 0.17 | <0.001 | ||||
| Female | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) | ||||
| Male | 1.359 (1.271–1.454) | <0.001 | 1.303 (1.235–1.374) | <0.001 | 1.050 (0.979–1.126) | 0.17 | 1.198 (1.133–1.266) | <0.001 |
| Age at diagnosis (years) | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| <40 | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) | ||||
| 40–49 | 2.295 (1.798–2.931) | <0.001 | 2.206 (1.798–2.705) | <0.001 | 1.339 (1.048–1.711) | 0.019 | 1.609 (1.311–1.974) | <0.001 |
| 50–59 | 3.391 (2.685–4.284) | <0.001 | 3.286 (2.704–3.993) | <0.001 | 1.581 (1.250–2.000) | <0.001 | 2.066 (1.698–2.513) | <0.001 |
| 60–69 | 3.968 (3.144–5.008) | <0.001 | 4.326 (3.565–5.251) | <0.001 | 1.894 (1.498–2.393) | <0.001 | 2.780 (2.288–3.378) | <0.001 |
| 70–80 | 4.440 (3.508–5.619) | <0.001 | 5.998 (4.938–7.285) | <0.001 | 2.415 (1.906–3.060) | <0.001 | 4.199 (3.454–5.105) | <0.001 |
| Marital status | 0.013 | <0.001 | <0.001 | <0.001 | ||||
| Married | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) | ||||
| Single | 1.087 (1.018–1.162) | 0.013 | 1.267 (1.203–1.335) | <0.001 | 1.204 (1.125–1.289) | <0.001 | 1.385 (1.312–1.461) | <0.001 |
| Grade | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| I | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) | ||||
| II | 1.644 (1.393–1.941) | <0.001 | 1.206 (1.092–1.332) | <0.001 | 1.168 (0.989–1.381) | 0.068 | 0.980 (0.886–1.083) | 0.687 |
| III | 5.837 (4.967–6.858) | <0.001 | 2.735 (2.477–3.019) | <0.001 | 2.148 (1.818–2.537) | <0.001 | 1.410 (1.271–1.563) | <0.001 |
| IV | 19.026 (16.110–22.469) | 7.728 (6.941–8.605) | <0.001 | 3.671 (3.079–4.376) | <0.001 | 2.395 (2.132–2.691) | <0.001 | |
| T | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| T1 | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) | ||||
| T2 | 5.211 (4.704–5.774) | <0.001 | 2.415 (2.234–2.611) | <0.001 | 2.724 (2.445–3.034) | <0.001 | 1.525 (1.405–1.655) | <0.001 |
| T3 | 10.283 (9.483–11.151) | <0.001 | 4.535 (4.288–4.796) | <0.001 | 3.545 (3.228–3.893) | <0.001 | 1.993 (1.866–2.130) | <0.001 |
| T4 | 31.072 (26.515–36.412) | <0.001 | 12.417 (10.769–14.316) | <0.001 | 3.864 (3.247–4.599) | <0.001 | 2.174 (1.861–2.539) | <0.001 |
| N | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| N0 | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) | ||||
| N1 | 10.850 (9.741–12.086) | <0.001 | 7.478 (6.759–8.274) | <0.001 | 1.784 (1.590–2.001) | <0.001 | 1.797 (1.612–2.004) | <0.001 |
| N2 | 14.948 (13.199–16.928) | <0.001 | 10.035 (8.910–11.303) | <0.001 | 2.383 (2.091–2.715) | <0.001 | 2.384 (2.103–2.703) | <0.001 |
| M | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| M0 | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) | ||||
| M1 | 15.854 (14.850–16.925) | <0.001 | 9.305 (8.788–9.852) | <0.001 | 4.962 (4.595–5.357) | <0.001 | 4.031 (3.765–4.316) | <0.001 |
| Nephrectomy | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| Partial | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) | ||||
| Total | 7.873 (6.807–9.106) | <0.001 | 3.649 (3.354–3.970) | <0.001 | 2.399 (2.058–2.796) | <0.001 | 1.790 (1.636–1.958) | <0.001 |
Abbreviation: HR, hazard ratio.