Table 3.

Associations Between Fitness, Fatness, and High Cardiometabolic Risk^a,b

Variable	Model 1, OR (95% CI)	Model 2, OR (95% CI)
Low peak oxygen uptake
Women (<25.7 mL/kg/min)	2.89 (1.96-4.24)	2.12 (1.41-3.20)
Men (<30.7 mL/kg/min)	2.71 (1.79-4.12)	2.04 (1.31-3.18)
Pooled	2.77 (2.09-3.66)	2.06 (1.53-2.77)
High body mass index
Women (≥25 kg/m)	3.86 (2.62-5.70)	3.17 (2.11-4.75)
Men (≥25 kg/m)	3.33 (2.16-5.12)	2.72 (1.73-4.28)
Pooled	3.58 (2.69-4.77)	2.94 (2.18-3.97)
High waist circumference
Women (≥88 cm)	3.74 (2.51-5.58)	3.03 (2.00-4.59)
Men (≥102 cm)	2.44 (1.57-3.78)	1.79 (1.11-2.87)
Pooled	3.06 (2.29-4.10)	2.39 (1.75-3.25)
High percent body fat
Women (≥35%)	3.02 (2.06-4.43)	2.29 (1.51-3.46)
Men (≥25%)	3.60 (2.38-5.44)	2.92 (1.85-4.62)
Pooled	3.26 (2.47-4.30)	2.54 (1.87-3.45)

^aHDL = high-density lipoprotein; OR = odds ratio.

^bHigh cardiometabolic risk defined as the presence of at least 2 of the following 4 risk factors: elevated triglyceride level (≥1.7 mmol/L) or pharmacological treatment of dyslipidemia; reduced HDL cholesterol (<1.3 mmol/L in women and <1.0 mmol/L in men) or pharmacological treatment of dyslipidemia; elevated blood pressure (systolic ≥130 mm Hg and/or diastolic ≥85 mm Hg) or pharmacological treatment of hypertension; and elevated fasting glucose level (≥100 mg/dL [to convert to mmol/L, multiply by 0.0555]) or pharmacological treatment of diabetes. Odds ratios are compared to the reference categories of either high peak oxygen uptake, low body mass index, low waist circumference, or low percent body fat. Model 1: Adjusted for age, smoking status, alcohol consumption, and physical activity (meeting/not meeting recommendation for moderate to vigorous physical activity). Pooled analyses for women and men are additionally adjusted for sex. Model 2: Adjusted as model 1 plus body mass index (entered as categorical variable) for peak oxygen uptake and peak oxygen uptake (entered as categorical variable) for body mass index, waist circumference, and percent body fat.