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. Author manuscript; available in PMC: 2018 Sep 12.
Published in final edited form as: Thromb Res. 2016 May;141(Suppl 2):S8–S11. doi: 10.1016/S0049-3848(16)30354-1

Figure 1. The role of FXI in thrombosis and hemostasis.

Figure 1

In addition to the activation of FIX, X and V (step 1), we hypothesize that FXIa promotes thrombin generation by enhancing the TF-FVIIa pathway (step 2), including via the inactivation of TFPIα from platelets and TFPIβ from endothelial cells. Moreover, we hypothesized that in hemostasis, the main activator of FXI is thrombin (a), while in thrombosis the main activator of FXI is FXIIa (b).