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. 2018 Sep 6;13:5187–5205. doi: 10.2147/IJN.S168556

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© 2018 Pan et al. This work is published and licensed by Dove Medical Press Limited

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p5RHH-JNK2 siRNA NPs selectively inhibit JNK2 expression at both mRNA and protein levels in aorta from ApoE^−/− mice on a Western diet.

Notes: (A) RT²-PCR results demonstrate the JNK2-mRNA knockdown by p5RHH-JNK2 siRNA NPs (n=7) compared to HBSS control (n=6, P=0.044) and p5RHH-scrambled siRNA NPs (n=6, P=0.027; one-way ANOVA followed with Scheffé post hoc test). (B) JNK1 mRNA expression is not affected by p5RHH-JNK2 siRNA NP treatment (n=6) compared to HBSS control (n=6). (C and D) Western blot results illustrate JNK2 protein knockdown by p5RHH-JNK2 siRNA NPs (n=5) compared to HBSS control (n=6, P=0.042; unpaired two-sided Student’s t-test). GAPDH was used as internal control. Data presented in dot plots with means ± SE. ^*P<0.05.

Abbreviations: ANOVA, analysis of variance; HBSS, Hanks’ Balanced Salt solution; NPs, nanoparticles; PCR, polymerase chain reaction; RT, reverse transcription; SE, standard error.