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. 2018 Sep 6;13:5187–5205. doi: 10.2147/IJN.S168556

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© 2018 Pan et al. This work is published and licensed by Dove Medical Press Limited

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p5RHH-JNK2 siRNA NPs reduce inflammatory signaling in atherosclerotic plaque.

Notes: (A and B) Representative confocal images of immunofluorescence stains exhibit reduced nuclear localization of p65 in atherosclerotic plaques from treated ApoE^−/− mice (B) (n=10) compared to HBSS control (A) (n=16, P<0.001). Arrows point to cells harboring nuclear p65. Insets highlight cells with (A) and without (B) nuclear p65. A and B were captured at magnification of 60×. (C) Quantification of cells with nuclear p65 in plaques. (D and E) Western blot results illustrate STAT3 protein knockdown by p5RHH-JNK2 siRNA NPs (n=5) compared to HBSS control (n=6) (P=0.004). GAPDH was used as internal control. Unpaired two-sided Student’s t-test used for statistical analysis. ^**P<0.01; ^***P<0.001.

Abbreviations: HBSS, Hanks’ Balanced Salt solution; NPs, nanoparticles.