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. 2018 Sep 6;13:5139–5158. doi: 10.2147/IJN.S167043

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© 2018 Liu et al. This work is published and licensed by Dove Medical Press Limited

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Photothermal effect, phase change, drug-release behavior, and in vitro PA and US imaging of FA-PEG-PLGA-Ptx@ICG-Pfh NPs.

Notes: (A) The concentration-dependent Photothermal heating curves of the NPs for 5 min laser irradiation. (B) Images of phase change of the NPs by microscopy. (C) Release behavior of Ptx from the FA-PEG-PLGA-Ptx@ICG-Pfh NPs with or without laser irradiation, (D) PA signals of the NPs at different concentrations, (F) B-mode and contrast enhanced ultrasound (CEUS) imaging of the NPs with the laser irradiation in phantom gel model, (E) Linearity curve of the PA signal and the concentration of NPs, (G) and (H) Echo intensity in B-mode and CEUS mode of NPs with the laser irradiation at different time.

Abbreviations: PA, photoacoustic; US, ultrasound; FA, folic acid; PEG, polyethylene glycol; PLGA, poly(lactide-co-glycolic acid); Ptx, paclitaxel; ICG, indocyanine green; Pfh, perfluorohexane; NPs, nanoparticles; CEUS, contrast-enhanced US.