Table 2.
Liver function, renal function, and routine blood-test data of mice at day 7 after intravenous injection of FA-PEG-PLGA-Ptx@ICG-Pfh NPs at 10, 25, and 50 mg/kg
| Dose of NP | Liver function
|
Renal function
|
Routine blood tests
|
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ALT (U/L) | P-value | AST (U/L) | P-value | BUN (mg/dL) | P-value | Cr (μmol/L) | P-value | WBCs (109/L) | P-value | RBCs (1012/L) | P-value | Hb (g/L) | P-value | Plt (109/L) | P-value | |
| 10 mg/kg | 39.36±4.75 | 0.106 | 107.40±25.23 | 0.148 | 21.57±2.16 | 0.156 | 76.30±17.14 | 0.845 | 3.2±0.8 | 0.661 | 9.24±0.46 | 0.906 | 134±5 | 0.693 | 528±313 | 0.928 |
| 25 mg/kg | 42.16±9.00 | 0.256 | 134.92±65.84 | 0.490 | 20.70±2.36 | 0.308 | 82.31±9.70 | 0.796 | 3.0±0.9 | 0.418 | 9.01±0.60 | 0.822 | 134±11 | 0.722 | 507±65 | 0.798 |
| 50 mg/kg | 43.00±4.93 | 0.325 | 145.23±25.89 | 0.693 | 19.17±2.90 | 0.773 | 84.87±24.78 | 0.652 | 3.1±1.0 | 0.492 | 8.76±0.30 | 0.557 | 133±5 | 0.595 | 634±208 | 0.463 |
| Saline | 48.30±12.01 | 158.79±76.01 | 18.58±4.65 | 78.89±23.60 | 3.5±1.2 | 9.16±1.94 | 138±29 | 540±117 | ||||||||
Abbreviations: FA, folic acid; PEG, polyethylene glycol; PLGA, poly(lactide-co-glycolic acid); Ptx, paclitaxel; ICG, indocyanine green; Pfh, perfluorohexane; NPs, nanoparticles; BUN, blood urea nitrogen; Cr, creatinine; WBCs, white blood cells; RBCs, red blood cells; Hb, hemoglobin; Plt, platelet; ALT, alanine aminotransferase; AST, aspartate aminotransferase.