Table 2. Testing for global and instrumental-specific pleiotropism.
Point estimates, confidence intervals, and P-values from linkage disequilibrium (LD) regression analysis, and MR-Egger methods. For MR-Egger, the intercept represents the average pleiotropic effect; an intercept significantly different from zero implies directional pleiotropy.
| LD regression results | ||||
|---|---|---|---|---|
| Trait | Heritability estimate | Genetic correlation | Standard error | P-value |
| TC | 0.2408 | 0.049 | 0.0635 | 0.4402 |
| TG | 0.2939 | 0.0322 | 0.0639 | 0.6143 |
| LDL | 0.2122 | 0.0729 | 0.066 | 0.2696 |
| HDL | 0.2499 | -0.0603 | 0.563 | 0.2834 |
| MR-Egger regression results | ||||||
|---|---|---|---|---|---|---|
| Trait | Estimate | Corrected standard error | CI lower | CI upper | P-value | |
| TC | intercept | 1.11x10-2 | 1.25x10-2 | -1.42x10-2 | 3.64x10-2 | 0.38 |
| slope | 0.16 | 0.33 | -0.51 | 0.83 | 0.64 | |
| TG | intercept | -1.13x10-2 | 1.10x10-2 | -3.38x10-2 | 1.12x10-2 | 0.31 |
| slope | 5.65x10-2 | 0.17 | -0.30 | 0.42 | 0.75 | |
| LDL | intercept | -3.41x10-3 | 7.67x10-3 | -1.91x10-2 | 1.23x10-2 | 0.66 |
| slope | 0.10 | 0.11 | -0.11 | 0.32 | 0.34 | |
| HDL | intercept | 2.23x10-3 | 5.58x10-3 | -8.94x10-3 | 1.34x10-2 | 0.69 |
| slope | -0.11 | 0.11 | -0.32 | 0.11 | 0.31 | |