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. 2018 Aug 30;3(6):e000305. doi: 10.1136/esmoopen-2017-000305

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© Author (s) (or their employer(s)) 2018. Re-use permitted under CC BY. Published by BMJ on behalf of the European Society for Medical Oncology.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Analysis of the rate of changes in CD8⁺ TILs, FOXP3⁺ TILs and the CFR and RFS and OS in patients with all breast cancer subtypes. Patients with a high rate of change in CD8⁺ TIL levels had significantly better RFS (A) and OS (B) than those with a low rate of change (p=0.005, p=0.032, log-rank, respectively). Patients with a low rate of change in FOXP3⁺ TIL levels had significantly better RFS (C) and OS (D) than those with a high rate of change (p=0.044, p=0.025, log-rank, respectively). Patients with a high rate of change in the CFR also had significantly better RFS (E) and OS (F) than those with a low rate of change (p<0.001, log-rank, both end points). Goto et al.17 CFR, CD8/FOXP3 ratio; FOXP3, forkhead box protein 3; OS, overall survival; RFS, recurrence-free survival; TIL, tumour-infiltrating lymphocyte.