Table 2.

Univariate and multivariate analyses with respect to recurrence-free survival in breast cancer subtypes

	Univariate analysis			Multivariate analysis
	HR	95% CI	P values	HR	95% CI	P values
All breast cancer (n=129)
Age (≤56 years)	1.406	0.729 to 2.755	0.309
Tumour size (>2 cm)	1.098	0.434 to 3.693	0.859
Lymph node (+)	2.004	0.895 to 5.342	0.095
Ki-67 (>14)	1.012	0.523 to 1.974	0.971
Subtype (TNBC)	1.494	0.553 to 4.706	0.441
Pathological response (non-PR)	6.327	2.893 to 13.133	<0.001	5.260	2.373 to 11.145	<0.001
TIL (%) change (low)	1.276	0.656 to 2.536	0.473
CD8 change (low)	3.114	1.430 to 7.773	0.003	2.304	1.052 to 5.776	0.036
FOXP3 change (high)	1.978	0.996 to 3.894	0.051
CFR change (low)	5.612	2.581 to 14.001	<0.001	4.663	2.133 to 11.682	<0.001
TNBC (n=39)
Age (≤56 years)	1.547	0.491 to 5.252	0.455
Tumour size (>2 cm)	0.261	0.066 to 1.721	0.139
Lymph node (+)	0.934	0.279 to 4.212	0.919
Ki-67 (>14)	1.138	0.358 to 4.264	0.832
Pathological response (non-PR)	25.642	6.873 to 123.724	<0.001	34.290	7.314 to 265.738	<0.001
TIL (%) change (low)	1.701	0.542 to 5.758	0.361
CD8 change (low)	2.339	0.697 to 10.551	0.177
FOXP3 change (high)	2.106	0.660 to 7.922	0.212
CFR change (low)	11.420	2.215 to 208.742	0.002	13.021	2.241 to 258.136	0.002
HRBC (n=77)
Age (≤56 years)	1.182	0.475 to 2.982	0.717
Tumour size (>2 cm)	3.622	0.743 to 65.248	0.128
Lymph node (+)	2.803	0.796 to 17.749	0.118
Ki-67 (>14)	0.781	0.305 to 1.969	0.597
Pathological response (non-PR)	2.132	0.488 to 6.625	0.277
TIL (%) change (low)	1.069	0.404 to 2.885	0.892
CD8 change (low)	3.167	1.134 to 11.196	0.027	2.746	0.976 to 9.741	0.056
FOXP3 change (high)	1.985	0.682 to 5.237	0.196
CFR change (low)	4.740	1.779 to 14.833	0.002	4.377	1.641 to 13.712	0.003

Values in parentheses are 95% CIs.

CFR, CD8/FOXP3 ratio; FOXP3, forkhead box protein; HRBC, hormone receptor-positive breast cancer; PR, partial response; TIL, tumour-infiltrating lymphocyte; TNBC, triple-negative breast cancer.