Table 3.

Univariate and multivariate analyses with respect to overall survival in breast cancer subtypes

	Univariate analysis			Multivariate analysis
	HR	95% CI	P values	HR	95% CI	P values
All breast cancer (n=129)
Age (≤56 years)	1.700	0.733 to 4.124	0.217
Tumour size (>2 cm)	1.421	0.415 to 8.901	0.619
Lymph node (+)	2.280	0.776 to 9.710	0.145
Ki-67 (>14)	1.272	0.547 to 3.092	0.578
Subtype (TNBC)	2.933	1.186 to 7.586	0.020	4.024	1.395 to 12.522	0.010
Pathological response (non-PR)	13.771	5.397 to 35.763	<0.001	15.564	5.368 to 48.819	<0.001
TIL (%) change (low)	1.316	0.568 to 3.191	0.524
CD8 change (low)	3.103	1.147 to 10.797	0.024	2.271	0.769 to 8.352	0.143
FOXP3 change (high)	2.586	1.086 to 6.230	0.032	0.773	0.262 to 2.325	0.640
CFR change (low)	8.279	2.800 to 35.365	<0.001	7.177	1.921 to 34.687	0.003
TNBC (n=39)
Age (≤56 years)	2.264	0.674 to 8.756	0.187
Tumour size (>2 cm)	0.349	0.089 to 2.303	0.232
Lymph node (+)	0.798	0.229 to 3.654	0.744
Ki-67 (>14)	1.648	0.475 to 7.542	0.446
Pathological response (non-PR)	11.812	0.043 to 23.141	<0.001	11.243	20.791 to 20.892	<0.001
TIL (%) change (low)	1.270	0.380 to 4.431	0.694
CD8 change (low)	1.822	0.525 to 8.340	0.358
FOXP3 change (high)	3.324	0.949 to 15.311	0.061
CFR change (low)	9.847	1.883 to 180.764	0.004	8.346	1.538 to 155.128	0.010
HRBC (n=77)
Age (≤56 years)	1.876	0.460 to 9.155	0.381
Tumour size (>2 cm)	6.474	0.716 to 0.716	0.092
Lymph node (+)	7.640	1.184 to 16.852	0.035	6.548	1.037 to 1.083	0.047
Ki-67 (>14)	0.955	0.225 to 4.054	0.948
Pathological response (non-PR)	3.235	0.473 to 14.085	0.198
TIL (%) change (low)	1.369	0.336 to 6.678	0.664
CD8 change (low)	5.283	0.939 to 98.783	0.060
FOXP3 change (high)	2.231	0.455 to 9.159	0.295
CFR change (low)	11.081	1.969 to 207.323	0.004	10.333	1.832 to 193.336	0.006

Values in parentheses are 95% CIs.

CFR, CD8/FOXP3 ratio; FOXP3, forkhead box protein; HRBC, hormone receptor-positive breast cancer; PR, partial response; TIL, tumour-infiltrating lymphocyte; TNBC, triple-negative breast cancer.