Table S1.
Search strategy
| PubMed via the NCBI Entrez system from inception to 1 September 2017 | ||
| #1 | “Carcinoma, Non-Small-Cell Lung” [Mesh] | 43491 |
| #2 | NSCLC [Title/Abstract] | 31187 |
| #3 | “Lung cancer*” [Title/Abstract] | 123251 |
| #4 | “Lung carcinoma*” [Title/Abstract] | 16074 |
| #5 | “Lung neoplasm*” [Title/Abstract] | 370 |
| #6 | “Lung tumor*” [Title/Abstract] | 5242 |
| #7 | “Lung tumour*” [Title/Abstract] | 833 |
| #8 | “Non-small-cell*” [Title/Abstract] | 48315 |
| #9 | “Non-small cell*” [Title/Abstract] | 48315 |
| #10 | “Non small-cell*” [Title/Abstract] | 48315 |
| #11 | “Non small cell*” [Title/Abstract] | 48315 |
| #12 | (#3 OR #4 OR #5 OR #6 OR #7) AND (#8 OR #9 OR #10 OR #11) | 46076 |
| #13 | #1 OR #2 OR #12 | 58288 |
| #14 | “Gemcitabine” [Supplementary Concept] OR “gemcitabine” [All Fields] | 14018 |
| #15 | “RRM1” [All Fields] OR “ribonucleotide reductase M1” [All Fields] OR “ribonucleotide reductase subunit M1” [All Fields] OR “ribonucleotide reductase large subunit” [All Fields] | 675 |
| #16 | #13 AND #14 AND #15 | 94 |
| EMBASE (via Elsevier) Search Strategy from 1980 to 1 September 2017 | ||
| #1 | “Lung cancer”/exp OR “lung cancer” | 345530 |
| #2 | “Non small cell lung cancer”/exp | 119859 |
| #3 | “Nonsmall cell”:tn,lnk,ab,ti | 4485 |
| #4 | “Lung tumor”/exp | 370444 |
| #5 | “Lung carcinoma”/exp | 171987 |
| #6 | “Lung neoplasm”:tn,lnk,ab,ti | 379 |
| #7 | “Lung tumour”/exp | 370444 |
| #8 | “Thoracic cancer”:tn,lnk,ab,ti | 297 |
| #9 | “Nsclc”:tn,lnk,ab,ti | 60146 |
| #10 | #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 | 393353 |
| #11 | “Gemcitabine”:tn,lnk,ab,ti | 23161 |
| #12 | “RRM1”:tn,lnk,ab,ti | 974 |
| #13 | “Ribonucleotide reductase m1”/exp | 113 |
| #14 | “Ribonucleotide reductase subunit m1”/exp | 30 |
| #15 | “Ribonucleotide reductase large subunit”/exp | 57 |
| #16 | #12 OR #13 OR #14 OR #15 | 1060 |
| #17 | #10 AND #11 AND #16 | 182 |
| Cochrane Library (from inception to 01 September 2017) Search Strategy | ||
| #1 | MeSH descriptor: [Lung Neoplasms] explode all trees | 6056 |
| #2 | MeSH descriptor: [Carcinoma, Non-Small-Cell Lung] explode all trees | 3099 |
| #3 | “Lung cancer*”:ti,ab,kw | 11984 |
| #4 | “Non-small cell*”:ti,ab,kw | 7740 |
| #5 | “Non small cell*”:ti,ab,kw | 7740 |
| #6 | “Nonsmall cell*”:ti,ab,kw | 277 |
| #7 | “Nsclc”:ti,ab,kw | 5108 |
| #8 | #1 or #2 or #3 or #4 or #5 or #6 or #7 | 13862 |
| #9 | Gemcitabine* | 3393 |
| #10 | “Ribonucleotide reductase subunit m1” | 7 |
| #11 | “Ribonucleotide reductase large subunit” | 1 |
| #12 | “Ribonucleotide reductase m1” | 9 |
| #13 | “RRM1” | 38 |
| #14 | #10 or #11 or #12 or #13 | 40 |
| #15 | #8 or #9 or #14 | 21 |
| CNKI Search Strategy from inception to 1 September 2017 | ||
| #1 | 肺癌 AND RRM1 AND 吉西他滨 | 50 |
| WanFang Database Search Strategy from inception to 1 September 2017 | ||
| #1 | 肺癌 AND RRM1 AND 吉西他滨 | 48 |