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. 2018 Sep 7;4(2):e000692. doi: 10.1136/rmdopen-2018-000692

Figure 4.

Figure 4

HAQ-DI LSM change from baseline (A), proportion of patients achieving HAQ-DI MCID (improvement ≥0.35) (B) and SF-36 PF LSM change from baseline (C) after 24 weeks in patients with PsA treated with PBO, IXEQ4W or IXEQ2W alone or when added to background cDMARDs or MTX. The treatment-by-cDMARD use interaction p-value was 0.040 for HAQ-DI, 0.1475 for HAQ-DI MCID, and 0.044 for SF-36 PF. *p<0.05, **p<0.01, ***p<0.001, all versus PBO. cDMARD, conventional disease-modifying antirheumatic drugs; CI, confidence interval; HAQ-DI, Health Assessment Questionnaire Disability Index; IXEQ4W, ixekizumab every 4 weeks; IXEQ2W, ixekizumab every 2 weeks; LSM, least squares mean; MCID, minimal clinically important difference; MTX, methotrexate; n, number of patients; PBO, placebo; SE, standard error; SF-36 PF, 36-item Short Form Survey physical functioning domain.