Fig 2. Evaluation of treatment efficacy.

A. Plasma viral loads are reported as RNA copies/ml and are shown group average (mean ± SEM). Longitudinal assessment of intracellular expression of three ISGs in PBMC by flow cytometry: B. IRF7, C. pSTAT1, D. IP-10. Data are reported as percentage of positive PBMC and are shown as group average (mean ± SEM) (solid line). The reported p values were calculated for the comparison of the AUC from week 8 to 60 and refer to AUC comparisons in paired groups. Between groups comparisons at individual time points were carried out with Wilcoxon-Mann-Whitney (rank sum) test. Asterisks mark significant time point paired comparisons for Group 3 vs. Group 4 (asterisks above brown line) or Group 5 vs. Group 6 (asterisks below blue line). The black, dotted line indicates the average of all 32 individual animal values measured before infection.