Fig 5. Longitudinal analysis of immune activation marker expression in tissue T cells of SIV-infected and treated or untreated RMs.

Data for lymph node and rectal tissue T-cell expression of immune activation markers, in biopsies collected at each PH-797804 treatment cycle start and end time points are shown. Panels report percentages HLADR⁺/CD38⁺/CD4+ (A) or Ki-67⁺/CD4⁺ T cells (B) in inguinal lymph nodes and in rectal mucosa (E and F, respectively), percentage of HLA-DR⁺/CD38⁺/CD8⁺ (C) or Ki-67⁺/CD8⁺ T cells (D) in lymph nodes and in rectal mucosa (G and H, respectively). Data are represented as group mean ± SEM. The black, dotted line indicates the average of all 32 individual animal values measured before infection. The reported p values were calculated for the comparison of the AUC from week 18 (first available time point after beginning of PH-797804 treatment) to 60 and refer to AUC comparisons in paired groups. Between groups comparisons at individual time points were carried out with Wilcoxon-Mann-Whitney (rank sum) test. Asterisks mark significant time point paired comparisons for Group 3 vs. Group 4 (asterisks above brown line) or Group 5 vs. Group 6 (asterisks below blue line).