Figure 8.

Survival of TRIM37 KD cells may depend on lysosomal functions. (a and b) HepG2 control and TRIM37 KD cells were treated without (-) or with (+) CQ (10 μM) for 16 h. (a) Cells were collected for PI staining to analyze the percentages of cell death. Data from triplicate samples in each group are presented as mean ± SEM and representative of 3 independent experiments; *: p < 0. 05; **: p < 0. 01; (Student’s t-test). (b) Cells were also collected for protein detection with the indicated antibodies. (c) HepG2 control and TRIM37 KD cells were grown in soft agar in the absence (-) or presence (+) of CQ (10 μM). The pictures were taken after 2 weeks.