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Genetic compensation rescues normal eye development in Atg14∆5.2 mutants. Atg14-specific RNAi treatment causes highly penetrant defects in eye development in both genders. A loss-of-function mutation in Atg14, ∆5.2, however, does not influence eye morphology. In Atg14∆5.2 mutants with no Atg14 transcript, the eye phenotype caused by Atg14 RNAi treatment is significantly suppressed (the mutation eliminates the transcript on which RNAi would act).
