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Representative model of SDCBP/MDA-9/Syntenin-mediated protective autophagy in anoikis-resistant GSCs. (A) SDCBP/MDA-9/Syntenin maintains protective autophagy in anoikis-resistant GSCs, whereas its loss deregulates this balance. (B) Schema of the multiple interconnected pathways that SDCBP/MDA-9/Syntenin regulates to maintain protective autophagy and anoikis-resistance in GSCs.
