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Virus-induced mitophagy attenuates RLR signaling. MFN1 and MFN2 promote fusion of mitochondria, which increases MAVS interaction with downstream signaling molecules to amplify RLR signaling and the type I IFN response. During infection, virus induces mitophagy to mitigate RLR signaling by degradation of MAVS or other strategies to favor viral replication.
