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. 2018 Jun 25;165(1):244–253. doi: 10.1093/toxsci/kfy158

Figure 1.

Figure 1.

CPF exposure alters pulmonary physiology in male and female rats. Voltage-response curves of (A) airway resistance (R) and (B) tissue elastance (E) response to electrical vagal stimulation of adult male rats dosed with vehicle (n = 12) or 30 mg/kg CPF, sc, at 24 h (n = 10) or 7 d (n = 14) post-injection. Voltage-response curves of (C) R and (D) E of female animals exposed to vehicle (n = 16) or 7 mg/kg CPF, sc, at 24 h (n = 8) or 7 d (n = 9) post-injection. Data presented as mean response ± SE (shaded regions). Voltage-response curves for male rats exposed to CPF at 10 mg/kg or 30 mg/kg at 48 h, 72 h, or 14 d post-injection are provided in Supplemental material. General linear mixed-effects models were fit up to 8 V to test whether the effect of voltage on R or E in CPF-exposed animals differed from vehicle control; *p < .05, **p < .01, ***p < .001 relative to vehicle control.