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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: J Mol Cell Cardiol. 2018 Jul 23;122:11–22. doi: 10.1016/j.yjmcc.2018.07.247

Figure 2. Rapid increase in the relative abundances of phosphorylated and degraded proteoforms of cTnI and ENH2 following increased temperature.

Figure 2.

Top-down mass spectra show that hyper-phosphorylation and truncation of cTnI occurred after tissue incubation at 4 °C (a) or 22 °C (b). Increased phosphorylation and degradation of ENH2 upon tissue defrosting at 4 °C (c) or 22 °C (d). Single, double, and triple circles denote singly-, doubly- and triply-oxidated proteoforms, respectively.