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. 2018 Aug 24;9(66):32580–32592. doi: 10.18632/oncotarget.25953

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Copyright: © 2018 Wu and Benavente

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A–D) Kaplan–Meier curves showing the survival of osteosarcoma-prone mouse models. (A) Mice bearing Rb1 mutations p53/Rb1 DKO: Osx-cre; p53^lox/lox; Rb1^lox/lox (black, n = 29) have significantly shorter lifespan compared to p53 cKO: Osx-cre; Tp53^lox/lox (red, n = 35). This survival time was significantly increased in (B) p53/Rb1/E2f1 TKO: Osx-cre; p53^lox/lox; Rb1^lox/lox; E2f1−/−(red, n = 25) and (C) p53/Rb1/E2f3 TKO: Osx-cre; p53^lox/lox;Rb1^lox/lox; E2f3^lox/lox (red, n = 34); but not in (D) p53/Rb1/E2f5 TKO: Osx-cre; p53^lox/lox;Rb1^lox/lox;E2f5^lox/lox (red, n = 22). Mantel-Cox test and Mantel-Haenszel hazard ratio (HR) were used for curve comparisons.