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. 2018 Aug 24;9(66):32580–32592. doi: 10.18632/oncotarget.25953

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Copyright: © 2018 Wu and Benavente

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A–B) Kaplan–Meier curves showing the survival of osteosarcoma-prone mouse models. Loss of Hells in osteosarcoma-prone mice show no changes in overall survival in (A) Tp53/Rb1/Hells TKO: Osx-cre; Tp53^lox/lox; Rb1^lox/lox; Hells ^lox/lox (red; n = 23) compared to p53/Rb1 DKO: Osx-cre; Tp53^lox/lox; Rb1^lox/lox (black; n = 24) nor (B) p53/Hells DKO: Osx-cre; p53^lox/lox; Hells ^lox/lox (red; n = 22) compared to p53 cKO: Osx-cre; p53^lox/lox (black; n = 35). Mantel-Cox test and Mantel-Haenszel hazard ratio (HR) were used for curve comparisons. (C) Western blot detection of HELLS confirms loss of HELLS protein in p53/Rb1/Hells TKO mice and p53/Hells DKO mice and HELLS expression in p53/Rb1 DKO and p53 cKO osteosarcoma tumors.