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. 2018 Sep 12;1:144. doi: 10.1038/s42003-018-0147-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Chronically implanted µIPs provide reliable longitudinal measurement over a wide range of dopamine concentrations and over the course of months postimplant. a Measured dopamine (DA) over time from three different probes, c121 (×), c122 (•), and c123 (○), in a single rat for a fixed stimulation parameter. b Recorded dopamine concentrations across time normalized to show fluctuations in measured dopamine release for each of 7 probes, c121 (•), c122 (⎕), c123 (◊), c171 (○), c172 (⊲), c201 (⊳), and c202 (▵), implanted in three rats. Stimulation parameters were fixed for each rat across measurement sessions. c Measured decay time from maximum to half-maximum evoked dopamine for same probes and parameters as in a. d Normalized decay times for same parameters and probes as in b. e Binned recorded dopamine concentrations detected by all functional probes (eight probes in four rats) and for the fixed stimulation parameters as in b and d, plotted by month. Error bars represent 95% confidence intervals