Table 1.
Trends of longitudinal changes in dopamine measured with chronically implanted µIPs
| Rat ID | Average DA for each rat (nM) | Standard deviation (nM) | Probe ID | Average DA for each probe (nM) | Standard deviation (nM) | Over time trend (nM/day) | Over time R | P-value |
|---|---|---|---|---|---|---|---|---|
| A | 446 | n/a | c081 | 446 | 138 | 1.5 | 0.7093 | 0.1797 |
| B | 60 | 2.5 | c121 | 57 | 20 | −0.17 | 0.61 | 0.2022 |
| B | c122 | 59 | 26 | −0.17 | 0.48 | 0.3369 | ||
| B | c123 | 63 | 13 | 0.34 | 0.7875 | 0.0630 | ||
| C | 39 | 1.4 | c171 | 40 | 18 | −0.10 | 0.1826 | 0.7688 |
| C | c172 | 38 | 9.2 | 0.07 | 0.2331 | 0.7059 | ||
| D | 179 | 73.5 | c201 | 127 | 50.2 | 0.28 | 0.1304 | 0.8344 |
| D | c202 | 231 | 125 | −4.82 | 0.8992 | 0.0378 |
Measured dopamine (DA) averaged across all recorded evoked signals from all chronic time points for each rat or for individual probes. Stimulation parameters are same as those implemented in Figs. 3e and 4a–c. Trend computed by taking the slope of a line fitted to recorded DA as a function of days. The R-value is Pearson’s correlation coefficient between measured DA and days, and its P-value tests the significance of R against a value of 0