Fig. 3.

Areas of significant decrease of [¹⁸F]MPPF binding following injection of NLX-112 at 0.04 mg/kg (a), 0.08 mg/kg (b) and 0.16 mg/kg (c) or NLX-101 at 0.04 mg/kg (d), 0.08 mg/kg (e) and 0.16 mg/kg (f) in cat brain (n = 4). Voxel-to-voxel statistical comparison between [¹⁸F]MPPF-specific binding from 60 to 90 min and [¹⁸F]MPPF-specific binding from 40 to 50 min (Student’s t test, p < 0.01). T scores in left scales. No voxel appeared significantly different between post injection and baseline following the injection of NaCl 0.9% (g). Ant Cing anterior cingulate cortex, Caud caudate nucleus, Coll colliculus, DRN dorsal raphe nucleus, Ent Ctx entorhinal cortex, Ins insula, LS lateral septum, Occ Ctx occipital cortex, Post Cing posterior cingulate cortex, RO raphe obscurus