Figure 6.

GCM has an extended therapeutic window for AILI compared with NAC. (A) C57BL/6N mice received GCM (50 mg·kg⁻¹, i.p.) or NAC (100, 200 or 300 mg·kg⁻¹, i.p.) at 2 h after acetaminophen (APAP) treatment, and serum ALT levels were determined at 24 h post‐acetaminophen. (B) Mice received NAC (300 mg·kg⁻¹) or PBS at 2, 3 or 4 h after acetaminophen (300 mg·kg⁻¹, i.p.) administration, and serum ALT levels were measured at 24 h post‐acetaminophen. (C) C57BL/6N mice received GCM (100 mg·kg⁻¹, i.p.) or NAC (300 mg·kg⁻¹, i.p.) at 4 h after acetaminophen treatment, and serum ALT levels were determined at 24 h post‐acetaminophen. (D) Representative images of haematoxylin and eosin‐stained liver sections at 100× magnification. Data are presented as mean ± SD for n = 6 mice per group. *P < 0.05 compared with the corresponding acetaminophen group.