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. 2018 Sep 12;4:97. doi: 10.1038/s41420-018-0100-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Western blot for the expression of human PIDD, actin and E1A in E1A-positive (H4-E1A), PIDD shRNA E1A+ cells (H4-E1AiPIDD) and E1A+ cells expressing scrambled control shRNA (H4-E1A scRNA). b Human fibrosarcoma cells H4, H4-E1A, H4-E1A iPDD, and H4-E1A scRNA treated with 750 μM DETA NONOate for 18 h. Cell viability was determined by MTS staining and expressed as % cell death (mean ± SEM; n = 4, ^***P < 0.001, one-way ANOVA). c Mouse NIH-3T3 cells 3T3, 3T3-E1A, 3T3-E1AiPIDD-1 and −2, and 3T3-E1A scRNA treated with 250 μM DETA-NONOate for 18 h. Cell viability was determined by MTS staining and expressed as % cell death (mean ± SEM; n = 3, ^***P < 0.001, ^**P = 0.0028, one-way ANOVA)